An alternative way of treating cancer
Using the body’s own controlling processes
as described in Chinese acupuncture,
expressed as peptides in the blood.
Are S. Thoresen DVM
Sergio Manzetti, M.Sc.
In 1975 Thoresen observed and discovered a method of treating breast cancer and other types of cancer with acupuncture. The method has been applied for over 25 years, on humans and dogs. In 2006 Thoresen and Manzetti identified in the blood of a woman with breast cancer the biochemical components that are responsible for the healing stimulated by the acupuncture treatment. The components, which are fragments of known and less known proteins, were tested on three breast cancer cell types, including a new and aggressive drug-resistant cell-type. The results have shown that the peptides in mixture have a stronger effect after only 24 hours than the chief-remedy in modern breast cancer therapy, Tamoxifen, in inhibiting cell-growth of three cell types, including a Tamoxifen-resistant strain. The results also showed that the peptides are not toxic even at a concentration 100-time higher than the toxic Tamoxifen. The acupuncture-induced peptides are the first unknown factors isolated after acupuncture stimulus, and their composition is entirely novel. Their human origin makes them more specific than today’s’ synthetic drugs and can not only prove to be better remedies than conventional drugs, but also prove to be a new way of discovering human remedies to human diseases. This new method relies on extracting knowledge from age-old acupuncture and translate it to factual medicines and better remedies and has been patented and is under publication.
- History and introduction.
- Thoresens theory and observations on cancer.
- PART I
- Scientific investigation
- Material and methods
- Samples and acupuncture-induced changes
- Identified Peptides
- Breast cancer cell tests
- Statistical analysis on the effect of the peptides
- PART II
- Clinical investigation
- Results I (human results)
- Results II (veterinary results)
- Closing remarks and comments
History and introduction
- First case of acupuncture treatment on cancer: In 1984 Thoresen first tried out a new method in treating cancer, with very promising results in a Dachshund (Thoresen, 2002). The diagnosis indicated malignant mammary cancer with spreading to the lungs. The dog was treated with acupuncture, using only one single point, chosen on the basis of Thoresens newly developed theory on acupuncture treatment of cancer (see below). A few weeks later the tumours had almost disappeared completely. The dog died several years later from a kidney deficiency.
- Publication on the method: In 1995 Thoresen treated a horse with Equine Sarcoid with good results, published in the Journal of the Norwegian veterinary Society, “Norsk Veterinærtidsskrift” (Thoresen 1995). This horse was also treated with just one needle, in the same way and based on the same theory as the Dachshund described above, although at a different point.
- The method in use today: Since 1984, Thoresen have treated more than 600 patients with various types of cancer according to the method described in this article (see below).
- Treatment and types of cancer: The results were particularly reproducible in mammary cancer (see results below) and in melanosarcoma. Results in lymphosarcoma and brain cancer were promising, but not as reproducible as in mammary cancer and melanosarcoma. The results in liver cancer were not good; the healing rate was zero in the few liver cancers that Thoresen has treated.
- Scientific study of the method: In 2004 Thoresen and Manzetti met at a seminar and decided to study the mechanisms of his acupuncture treatment on cancer. Samples were taken 2 years later from a patient with breast cancer and analyzed in USA, at the University of Minnesota. The results showed distinct and identifiable changes in the blood of the patient after treatment. The changes where tracked and re-synthesized, and tested on live breast cancer cells at the University of Massachusetts, Amherst, in Prof. Arcaros Lab, Department of Veterinary Medicine. The results are shown below.
- Today: Thoresen and Manzetti are looking for an investor to finance the development of the identified peptides as medicine for the treatment of breast cancer.
Thoresens theory and observations on cancer.
- Cancer-cells develop all the time in the body, but the body’s own controlling systems kill such cells effectively. Usually this control is thought to be executed by the immune system, and several cancer treatments, at least alternative ones, are based upon stimulation of the immune system.
- However, the results and conclusions drawn by the results in Thoresens treatment protocol indicate that not only the immune system is important in defeating cancer, but that all the organs and organ processes may be involved in a sophisticated feed-back control system for cell growth. This feed-back control system is described in Chinese acupuncture as “the co-cycle”. In this system heart controls lung, lung controls liver, liver controls spleen, spleen controls kidney and kidney controls heart.
- As an example of treatment, we will choose breast cancer. The breasts are situated exactly on the stomach meridian. So, if a cancer develops in the area or processes related to the stomach (to which the breast belongs), then the liver does not control the stomach properly. Consequently the liver has to be treated.
As treatment Thoresen uses just one effective acupuncture point belonging to the liver meridian, and he has chosen a point called liver 03.
Figure 1; the controlling sequence of the processes of the body according to acupuncture.
On this basis and with this method we will now investigate the effect on cancer, both clinically (Part I) and scientifically (Part II).
UNIVERSITY OF MASSACHUSETTS
N235 Morill 1
639 North Pleasant street
Amherst, MA 01003-9298
Department of Veterinary
and Animal Sciences
Kathleen F. Arcaro, Ph.D.
Phone: (413) 577 1823
Fax (413) 545 5731
Report on Peptides (December 07) tested in the Laboratory of Kathleen F. Arcaro, University of Massachusetts at Amherst, MA
During the period of December 13th through December 22, 2006 we prepared and tested 12 peptides in proliferation assays using three human breast cancer cell lines; T47D, MCF-7 and TMX2-28. The T47D and MCF-7 breast cancer cell lines were obtained from the American Type Culture Collection (ATCC) and details of the cell lines and conditions for their maintenance can be obtained from the ATCC website ( http://www.atcc.org/). The TMX2-28 cell line is a Tamoxifen-selected derivative of MCF-7, which lacks the oestrogen receptor, and is characterized by aggressive and invasive growth (see Gozgit et al., 2006 for details).
All following sections where written based on the results gained at University of Massachusetts. The written text is mixed with other parts of the study that may not derivate from the original document from the University of Massachusetts. The original document can be retrieved at request from the authors of this study after publication.
Because of publication being underway we have to limit this section to an abstract given the Journals request. However, we will update this document as soon as possible.
This first-time in history isolation of novel components of a healing process stimulated by acupuncture has been patented and is under publication. The value of a novel remedy for breast cancer of human origin has not been calculated yet, however several companies are investing between 500-2000 million USD in the production and marketing of drugs of synthetic origin. This may raise the value of these human-originated bioactive peptides to a minimum of this value.
Figures below indicate the effect of the peptide mixture on the three breast cancer cell lines. Not the highest effect on the most aggressive and drug-resistant TMX2-28. The peptide mixture as also been tested for cytotoxicity, see figures 4 and 5.
Fig1: Bioactive Peptide mixture cell-growth inhibiting effect on TMX2-28 (Tamoxifen resistant) cell lines.
Fig2: Bioactive Peptide mixture cell-growth inhibiting effect on MCF-7 cell lines.
Fig3: Bioactive Peptide mixture cell-growth inhibiting effect on T47D cell lines.
Fig 4. Cytotoxicity assay of the peptide mixture on MDA-MB-435 cells. The plots show no negative effects towards the cell’s viability compared to the the negative control (Untreated, first bar to the left). The 6 concentrations as tested in the breast cancer anti-proliferation assay show all to be affecting the viability positively.
Fig 4b. Cytotoxicity assay of the Tamoxifen on MDA-MB-435 cells. The plots show a reduced viability reaching ~80% cell-count reduction at 10-5M and at 10-4M indicating toxic effects on the cells compared to the negative control (Untreated, first bar to the left). Accounting for that this is the central remedy in todays breast cancer therapy, a significant potential of the peptide mixture to reduced (perhaps abolish) side-effects and increase therapeutic strength is evident.
Effects of the peptide individually towards the breast cancer cell lines TMX2-28, MCF7 and T47D.
The sequence of the peptides is not disclosed. Table 1 below indicates the induced effect on the growth of the three cell lines, by the twelve peptides alone. The arrows indicated the overall effect at the 6 concentration dose-response assay. The arrows pointing down indicate cell-growth inhibition, while the arrows pointing upwards indicate cell-growth induction. The nature of action of the peptides alone and in mix is the cornerstone of future work on their function and which mechanisms they stimulate.
Table 1. The twelve peptides with their given names and their effect on the three breast cancer cell lines.
Following below is a figure 5 with plots from the dose-response assay of selected peptides of the twelve. Controls are: DMSO (contains cells + 0.001% DMSO), positive control BAP/Tamoxifen (contains cells + Benzo[a]pyrene or Tamoxifen) and negative control DC5 (contains only medium).
Results I (human results)
The 18 human cases described represent a consecutive case series, of all human patients with benign or malignant tumours, seen between April 2003 and April 2004. They were not selected to show the best outcomes. Patients treated before April 22nd 2003 who returned for follow-up treatment or further examination within this period were included. Results are updated until April 2004.
Table 1: Summary of human treatment protocols and their interim outcomes
Table 1: Summary of human treatment protocols and their interim outcomes
Results II (veterinary results)
The 16 veterinary cases described represent a consecutive case series, of all patients with benign or malignant tumours, seen between April 2003 and April 2004. They were not selected to show the best outcomes. Patients treated before April 22nd 2003 who returned for follow-up treatment or further examination within this period were included. Results are updated until April 2004.
Table 2: Summary of veterinary treatment protocols and their interim outcomes
Closing remarks and comments
On this investigation;
This investigation show one thing very clearly, and that is the ability of the body to heal itself. This ability is from time to time shown in the fact that most diseases, even cancer, may suddenly self-heal. This phenomenon is utterly disregarded by the medical society, as this show to the ability of all life to self heal. We just have to find what happen in the body that triggers this self healing ability. The authors have used acupuncture to trigger the healing, but acknowledge that quite many other modalities may act in the same way, as imaging, herbal medicine, meditation, osteopathy and surely many more.
In practical life there may be a number of factors that are able to trigger such a self healing. Therefore the medical society may be confused to what actually happen, and just label the phenomenon as “placebo”.
The authors of this article, however, regard the organism as a holistic entity, with multiple layers of action and feed-back control. Therefore an intervention on just one of these levels may trigger the complete and whole organism to respond. We have thus focused on one such level, the peptide level or mechanisms. Changes in the concentrations or presence of bio-active oligopeptides are an expression of a change in the whole organism, and will act also as a signalling force for the multitude of layers and levels in the body. The authors are convinced that such a change also may occur at other systems, and that the same may be found there, also inducing healing, but we have decided to concentrate on the peptides.
On the possibility of treating cancer with one needle acupuncture;
As the scientific investigations show that Thoresen's clinical results may be correct, then this opens the possibility to treat cancer with just one needle, or with the peptides emerging after this one needle. We then have two possibilities to treat, one expensive (injecting the peptides as a medical treatment), but also the cheap version of treating with acupuncture. This last possibility may show very important for areas of the world with many poor people.
On the action of acupuncture;
Acupuncture is usually considered to have its action through the nervous system, and many investigations and much thought is initiated to map out the working mechanisms here. This investigation however, shows that the blood may be of greater importance than we have thought. The whole action of acupuncture may in some cases be explained by the mere action of peptides in the blood, and these peptides are not produced by the nervous tissue, but by cutting parts of proteins already available in the blood stream. There are already some indications that this may be true. I will here mention the old medical knowledge that if the diseased area, muscle, joint or organ gets a good blood supply, then healing is often induced. Also the work of Dr. Björn Nordenström shows that the acupuncture meridians and points are more related to the blood vessels than the nerves, and this indicate the importance of the blood in the healing process.
On treating other diseases with acupuncture;
If cancer may be cured with such peptides, there are several diseases that also may be cured that way. The authors are presently engaged in mapping out this, and are working with such diseases as Horton headache, MS and several muscular and rheumatoid syndromes.
On the possibility of composing new medicines based on peptides;
As long as various diseases show a good reaction after acupuncture, even if this may be a minority of the patients, there will be the possibility to map out what peptides are active in the response and produce medicines from those. This will be a cheap and safe way to find new medicines, regarding the low possibility of harmful effects from the medicines, as they already are composed by the body itself.
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- Thoresen A, Veterinærmedisin, Komplementære og Alternative metoder, pp.442-445, ISBN 82-994172-4-4, 621 pages. English edition; ISBN 82-994172-2-8, gages 358-363.
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